mirrors and proxies options via profiles

Depending what office I'm working in, if I'm at home, if I'm a vpn or not I have to change my mirror and proxy settings.

One office has a slow internet connection so has a local mirror (aka nexus).
Another office also has a local mirror (but artifactory not nexus) so it's on a different url.

So being able to enable mirrors and proxies via profiles would be very helpful.